Aptima® BV &
CV/TV Assays
Accurate Results Optimize Care
Testing is critical for the correct treatment. While yeast infection or candida vaginitis (CV) is usually a result of overgrowth of Candida albicans, it can also be caused by the often azole-resistant strain Candida glabrata, which requires a different treatment pathway.1 Trichomoniasis (“Trich”), the most common curable STI, can contribute to more serious health outcomes if left untreated.1,2 Our assays detect the three most common causes of infectious vaginitis–bacterial vaginosis (BV), candida vaginitis (CV) and Trichomonas vaginalis (TV).3-7
30%
of symptomatic women will remain undiagnosed after clinical evaluation for vaginitis.8,9
90%
of vaginitis is caused by BV, CV and TV infections, either individually or in combination.5
21M
women in the US are impacted by bacterial vaginosis alone.1,10
Clear the Confusion Around Coinfection
Pathogen coinfection can occur frequently in women with vaginitis.11 The CDC recommends all women diagnosed with BV be tested for STIs.1
~36% of women with BV
were also infected with TV and/or Candida species12
Most conventional methods of diagnosis—including wet mount, microscopy, or laboratory examination—lack accuracy and are also not easily available.12,13 In contrast, NAAT molecular tests are highly sensitive, able to detect more co-infection cases than wet mount, culture, and Amsel’s criteria.12
Assays Designed for Maximum Performance
Aptima® BV Assay
Our assay was thoughtfully developed using insights from key opinion leaders, comprehensive literature review, extensive clinical studies and a robust clinical trial.6,12,14,15 Over 100 algorithms were evaluated to maximize sensitivity and specificity.16
Using a proprietary algorithm, the Aptima® BV Assay quantitatively detects these three target organisms. It then delivers a single, qualitative result for BV.6
Lactobacillus spp.
(L. gasseri, L. crispatus, L. jensenii)
G. vaginalis
A. vaginae
Aptima® CV/TV Assay
To help deliver clinically meaningful results, our assay detects and differentiates microorganisms associated with CV* and TV.7
Our Aptima® CV/TV Assay delivers three positive or negative results:7
Candida species group (C. albicans, C. tropicalis, C. parapsilosis, C. dubliniensis)
Candida glabrata
Trichomonas vaginalis
*Although C. krusei can also be associated with azole resistance, this target was not included in our assay design due to its extremely low prevalence.17
DNA Probe Method is Less Comprehensive, Less Sensitive and Lacks Specificity
Let’s Connect
Have a question or need to talk to a Hologic team member? We’re here to help.